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The physicians in our directory are members of a Children’s Health hospital medical staff or are credentialed by Children’s Health for managed care participation. Some physicians are employed by Children’s Health, some are employed elsewhere, and some maintain an independent medical practice. There is no fee for being listed in our directory. The physicians populating your search results are selected based on the criteria that you provide and are then listed alphabetically. If a physician is no longer on a Children’s Health medical staff or participating in a Children’s Health managed care agreement, he/she would not be eligible to be listed in our directory.

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Ralph John DeBerardinis, MD $$

Pediatric Genetics Specialist

Professor at UT Southwestern Medical Center

Languages Spoken:
English
UT Southwestern Pediatric Group

Biography

Ralph DeBerardinis, M.D., Ph.D., is a Medical Geneticist at Children’s Health℠ and faculty member at UT Southwestern Medical Center. His clinical care focuses on pediatric genetics and newborn screening for metabolic disorders, and his research focuses on the role of altered metabolism in cancer and childhood genetic diseases. He is considered an international leader in research on cancer metabolism.

Dr. DeBerardinis earned his M.D. and Ph.D. at the University of Pennsylvania. He completed residencies in pediatrics and medical genetics and a fellowship in clinical biochemical genetics at Children’s Hospital of Philadelphia.

Dr. DeBerardinis is currently a Professor in the Children’s Medical Center Research Institute (CRI) and Department of Pediatrics at UT Southwestern. He is the Robert L. Moody, Sr. Faculty Scholar, Sowell Family Scholar in Medical Research and the Joel B. Steinberg, M.D. Chair in Pediatrics at UT Southwestern. He serves as Chief of Pediatric Genetics and Metabolism at UT Southwestern and Director of the Genetic and Metabolic Disease Program in the CRI. In 2018 he was appointed as an Investigator in the Howard Hughes Medical Institute.

Dr. DeBerardinis has published more than 170 articles and chapters on the role of perturbed metabolic states in human health and disease. He serves on editorial boards of several major biomedical journals, including eLife and Cancer Discovery. He is a member of the American Association for Cancer Research, Society for Pediatric Research, American Society of Human Genetics and Society for Inherited Metabolic Disorders. He has been elected to the American Society for Clinical Investigation and named to D Magazine’s list of Best Pediatric Subspecialists. Dr. DeBerardinis has trained and advised dozens of medical students, residents, postdoctoral trainees and visiting scientists.

Education and Training

Medical School
University of Pennsylvania School of Medicine (2000)
Residency
Children's Hospital of Philadelphia (2005), Medical Genetics
Board Certification
American Board of Medical Genetics and Genomics

Conditions

Departments and Programs

  • Research Interests

    • Cancer
    • Genetic disorders in children
    • Inborn errors of metabolism
    • Metabolism

    To learn more about Dr. Deberardinis's research, visit the Children’s Medical Center Research Institute at UT Southwestern.

  • Publications

    • Mitochondrial complex I promotes kidney cancer metastasis. Bezwada D, Perelli L, Lesner NP, Cai L, Brooks B, Wu Z, Vu HS, Sondhi V, Cassidy DL, Kasitinon S, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, McDaniel P, Sudderth J, Dumesnil D, House S, Rosales T, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Garcia-Bermudez J, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Genovese G, Margulis V, DeBerardinis RJ, Nature 2024 Aug
    • Electron transport chain inhibition increases cellular dependence on purine transport and salvage. Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ, Cell Metab 2024 Jun
    • Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples. Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ, Cell Metab 2023 Aug
    • In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ, Sci Adv 2022 Dec 8 50 eabp8293
    • In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors. Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJ, Sci Adv 2022 Sep 8 35 eabn9550
    • Compartmentalized metabolism supports midgestation mammalian development. Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ, Nature 2022 04 604 7905 349-353
    • Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ, J Clin Invest 2021 Jan 131 1
    • Tumor Microenvironment, Metabolism, and Immunotherapy. DeBerardinis RJ, N Engl J Med 2020 02 382 9 869-871
    • Metabolic heterogeneity confers differences in melanoma metastatic potential. Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ, Nature 2020 01 577 7788 115-120

  • Professional Activities

    • American Association for Cancer Research
    • American Society for Clinical Investigation (2013)
    • American Society of Human Genetics
    • Investigator, Howard Hughes Medical Institute (2018)
    • National Academy of Medicine (2020)
    • Society for Inherited Metabolic Disorders
    • Society for Pediatrics Research

  • Awards and Honors

    • Paul Marks Prize for Cancer Research (2021)
    • National Academy of Medicine (2020)
    • D Magazine Best Pediatric Specialists (2016, 2018-2020)
    • National Academy of Medicine(2020)
    • Howard Hughes Medical Institute Investigator (2018)
    • Howard Hughes Medical Institute Faculty Scholar (2017)
    • NCI Outstanding Investigator (2017)
    • Robert L. Moody, Sr. Faculty Scholar (2017)
    • Damon Runyon Cancer Research Foundation Clinical Investigator Award (2011)
    • President’s Research Council Distinguished Young Researcher Award (2008)
    • Soc. for Inherited Metabolic Disorders Neil Buist Award (2008)
    • Sowell Family Scholar in Medical Research (2008)
    • William K. Bowes, Jr. Award in Medical Genetics (2008)
    • CHOP Pediatric Scholars Program & Faculty Honor Roll (2007)
    • American Society for Clinical Investigation

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